Title : Demethylation-mediated miR-129-5p up-regulation inhibits malignant phenotype of osteogenic osteosarcoma by targeting Homo sapiens valosin-containing protein (VCP).

Pub. Date : 2015 May

PMID : 25566966






2 Functional Relationships(s)
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1 In addition, three CPG islands in the region of miR-129-5p promoter were detected by bioinformatical prediction, and significantly higher expression of miR-129-5p and lower methylation level of miR-129-2 gene in OS cells treated with 5-Aza-2"-deoxycytidine (a potent DNA demethylating agent) than in those untreated cells were observed. Decitabine microRNA 1295a Homo sapiens
2 In addition, three CPG islands in the region of miR-129-5p promoter were detected by bioinformatical prediction, and significantly higher expression of miR-129-5p and lower methylation level of miR-129-2 gene in OS cells treated with 5-Aza-2"-deoxycytidine (a potent DNA demethylating agent) than in those untreated cells were observed. Decitabine microRNA 1295a Homo sapiens