Title : Long-term effects of maternal citrulline supplementation on renal transcriptome prevention of nitric oxide depletion-related programmed hypertension: the impact of gene-nutrient interactions.

Pub. Date : 2014 Dec 15

PMID : 25517031






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 L-citrulline (CIT) can be converted to L-arginine to generate nitric oxide (NO). Citrulline citron rho-interacting serine/threonine kinase Rattus norvegicus
2 L-citrulline (CIT) can be converted to L-arginine to generate nitric oxide (NO). Arginine citron rho-interacting serine/threonine kinase Rattus norvegicus
3 L-citrulline (CIT) can be converted to L-arginine to generate nitric oxide (NO). Nitric Oxide citron rho-interacting serine/threonine kinase Rattus norvegicus
4 We examined whether maternal CIT supplementation can prevent N(G)-nitro-L-arginine-methyl ester (L-NAME, NO synthase inhibitor)-induced programmed hypertension and examined their effects on the renal transcriptome in male offspring using next generation RNA sequencing (RNA-Seq) technology. NG-Nitroarginine Methyl Ester citron rho-interacting serine/threonine kinase Rattus norvegicus
5 L-NAME exposure induced hypertension in the 12-week-old offspring, which CIT therapy prevented. NG-Nitroarginine Methyl Ester citron rho-interacting serine/threonine kinase Rattus norvegicus