Pub. Date : 2010
PMID : 25506968
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex Advances in pharmacological approaches to target the ubiquitin-proteasome system have revealed several potential new molecular targets within the ubiquitin machinery. | ML323 | ubiquitin specific peptidase 1 | Homo sapiens |
| 2 | Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex Advances in pharmacological approaches to target the ubiquitin-proteasome system have revealed several potential new molecular targets within the ubiquitin machinery. | ML323 | WD repeat domain 48 | Homo sapiens |
| 3 | Herein, we describe the discovery and optimization of ML323, a probe molecule that displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1. | ML323 | ubiquitin specific peptidase 1 | Homo sapiens |
| 4 | Herein, we describe the discovery and optimization of ML323, a probe molecule that displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1. | ML323 | WD repeat domain 48 | Homo sapiens |
| 5 | In addition, ML323 potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1 [8]. | ML323 | proliferating cell nuclear antigen | Homo sapiens |
| 6 | In addition, ML323 potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1 [8]. | ML323 | FA complementation group D2 | Homo sapiens |
| 7 | In addition, ML323 potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1 [8]. | ML323 | ubiquitin specific peptidase 1 | Homo sapiens |
| 8 | In addition, ML323 potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1 [8]. | ML323 | WD repeat domain 48 | Homo sapiens |