| Protein Name | proliferating cell nuclear antigen |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5111 |
| Gene Symbol | PCNA |
| UniProt | P12004 (PCNA_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
934
Total Number of Articles : 1640 |
Description |
proliferating cell nuclear antigen |
| Gene Summary |
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008] |
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| Properties | |