Pub. Date : 2015 Feb 1
PMID : 25445786
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present work we report the role of one of the least explored Sirtuin viz., SIRT7, under conditions of genomic stress when treated with doxorubicin. | Doxorubicin | sirtuin 7 | Homo sapiens |
| 2 | SIRT7 overexpressing cells when treated with low dose of doxorubicin (0.25 microM) showed delayed onset of senescence, lesser accumulation of DNA damage marker gammaH2AX and lowered levels of growth arrest markers viz., p53 and p21 when compared to doxorubicin treated control GFP expressing cells. | Doxorubicin | sirtuin 7 | Homo sapiens |
| 3 | SIRT7 overexpressing cells when treated with low dose of doxorubicin (0.25 microM) showed delayed onset of senescence, lesser accumulation of DNA damage marker gammaH2AX and lowered levels of growth arrest markers viz., p53 and p21 when compared to doxorubicin treated control GFP expressing cells. | Doxorubicin | sirtuin 7 | Homo sapiens |
| 4 | When treated with higher dose of doxorubicin (>1 microM), SIRT7 conferred resistance to apoptosis by attenuating stress activated kinases (SAPK viz., p38 and JNK) and p53 response thereby shifting the cellular fate towards senescence. | Doxorubicin | sirtuin 7 | Homo sapiens |
| 5 | SIRT7 mediated resistance to doxorubicin induced apoptosis and senescence was lost when p53 level was restored by nutlin treatment. | Doxorubicin | sirtuin 7 | Homo sapiens |