Title : Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.

Pub. Date : 2014 Dec 26

PMID : 25415648






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hydantoin 13 had excellent selectivity over other zinc metalloproteases such as TACE, MMP2, MMP3, MMP13, and MMP14. hydantoin 13 matrix metallopeptidase 14 Rattus norvegicus