Pub. Date : 2014 Dec
PMID : 25186948
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine hydroxymethyltransferase (SHMT2), is induced when MYC-transformed cells are subjected to hypoxia. | Serine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 2 | In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine hydroxymethyltransferase (SHMT2), is induced when MYC-transformed cells are subjected to hypoxia. | Serine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 3 | In mitochondria, SHMT2 can initiate the degradation of serine to CO2 and NH4+, resulting in net production of NADPH from NADP+. | Serine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 4 | In mitochondria, SHMT2 can initiate the degradation of serine to CO2 and NH4+, resulting in net production of NADPH from NADP+. | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | serine hydroxymethyltransferase 2 | Homo sapiens |
| 5 | In mitochondria, SHMT2 can initiate the degradation of serine to CO2 and NH4+, resulting in net production of NADPH from NADP+. | Ammonium Compounds | serine hydroxymethyltransferase 2 | Homo sapiens |
| 6 | In mitochondria, SHMT2 can initiate the degradation of serine to CO2 and NH4+, resulting in net production of NADPH from NADP+. | NADP | serine hydroxymethyltransferase 2 | Homo sapiens |
| 7 | In mitochondria, SHMT2 can initiate the degradation of serine to CO2 and NH4+, resulting in net production of NADPH from NADP+. | NADP | serine hydroxymethyltransferase 2 | Homo sapiens |
| 8 | Knockdown of SHMT2 in MYC-dependent cells reduced cellular NADPH:NADP+ ratio, increased cellular reactive oxygen species, and triggered hypoxia-induced cell death. | NADP | serine hydroxymethyltransferase 2 | Homo sapiens |
| 9 | Knockdown of SHMT2 in MYC-dependent cells reduced cellular NADPH:NADP+ ratio, increased cellular reactive oxygen species, and triggered hypoxia-induced cell death. | NADP | serine hydroxymethyltransferase 2 | Homo sapiens |
| 10 | Knockdown of SHMT2 in MYC-dependent cells reduced cellular NADPH:NADP+ ratio, increased cellular reactive oxygen species, and triggered hypoxia-induced cell death. | Reactive Oxygen Species | serine hydroxymethyltransferase 2 | Homo sapiens |
| 11 | SIGNIFICANCE: In this study, we demonstrate that the mitochondrial enzyme SHMT2 is induced upon hypoxic stress and is critical for maintaining NADPH production and redox balance to support tumor cell survival and growth. | NADP | serine hydroxymethyltransferase 2 | Homo sapiens |