Title : PGC-1α and PGC-1β increase CrT expression and creatine uptake in myotubes via ERRα.

Pub. Date : 2014 Dec

PMID : 25173818






2 Functional Relationships(s)
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1 PGC-1alpha and PGC-1beta increase CrT expression and creatine uptake in myotubes via ERRalpha. Creatine PPARG coactivator 1 beta Homo sapiens
2 Here we show that adenoviral overexpression of PGC-1alpha or PGC-1beta in L6 myotubes increased CrT mRNA (2.1 and 1.7-fold, P<0.0125) and creatine uptake (1.8 and 1.6-fold, P<0.0125), and this effect was inhibited with co-expression of shRNA for ERRalpha. Creatine PPARG coactivator 1 beta Homo sapiens