PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25173818-0 2014 PGC-1alpha and PGC-1beta increase CrT expression and creatine uptake in myotubes via ERRalpha. Creatine 53-61 PPARG coactivator 1 alpha Homo sapiens 0-10 25173818-0 2014 PGC-1alpha and PGC-1beta increase CrT expression and creatine uptake in myotubes via ERRalpha. Creatine 53-61 PPARG coactivator 1 beta Homo sapiens 15-24 25173818-0 2014 PGC-1alpha and PGC-1beta increase CrT expression and creatine uptake in myotubes via ERRalpha. Creatine 53-61 estrogen related receptor alpha Homo sapiens 85-93 25173818-1 2014 Intramuscular creatine plays a crucial role in maintaining skeletal muscle energy homeostasis, and its entry into the cell is dependent upon the sodium chloride dependent Creatine Transporter (CrT; Slc6a8). Creatine 14-22 solute carrier family 6 member 8 Homo sapiens 198-204 25173818-1 2014 Intramuscular creatine plays a crucial role in maintaining skeletal muscle energy homeostasis, and its entry into the cell is dependent upon the sodium chloride dependent Creatine Transporter (CrT; Slc6a8). Sodium Chloride 145-160 solute carrier family 6 member 8 Homo sapiens 198-204 25173818-7 2014 We therefore hypothesized that PGC-1 and ERRalpha could also regulate CrT gene expression and creatine uptake in skeletal muscle. Creatine 94-102 PPARG coactivator 1 alpha Homo sapiens 31-36 25173818-7 2014 We therefore hypothesized that PGC-1 and ERRalpha could also regulate CrT gene expression and creatine uptake in skeletal muscle. Creatine 94-102 estrogen related receptor alpha Homo sapiens 41-49 25173818-8 2014 Here we show that adenoviral overexpression of PGC-1alpha or PGC-1beta in L6 myotubes increased CrT mRNA (2.1 and 1.7-fold, P<0.0125) and creatine uptake (1.8 and 1.6-fold, P<0.0125), and this effect was inhibited with co-expression of shRNA for ERRalpha. Creatine 141-149 PPARG coactivator 1 alpha Homo sapiens 47-57 25173818-8 2014 Here we show that adenoviral overexpression of PGC-1alpha or PGC-1beta in L6 myotubes increased CrT mRNA (2.1 and 1.7-fold, P<0.0125) and creatine uptake (1.8 and 1.6-fold, P<0.0125), and this effect was inhibited with co-expression of shRNA for ERRalpha. Creatine 141-149 PPARG coactivator 1 beta Homo sapiens 61-70 25173818-9 2014 Overexpression of a constitutively active ERRalpha (VP16-ERRalpha) increased CrT mRNA approximately 8-fold (P<0.05), resulting in a 2.2-fold (P<0.05) increase in creatine uptake. Creatine 168-176 estrogen related receptor alpha Homo sapiens 42-50 25173818-9 2014 Overexpression of a constitutively active ERRalpha (VP16-ERRalpha) increased CrT mRNA approximately 8-fold (P<0.05), resulting in a 2.2-fold (P<0.05) increase in creatine uptake. Creatine 168-176 estrogen related receptor alpha Homo sapiens 57-65