Pub. Date : 2014 Aug 28
PMID : 25170806
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells. | Curcumin | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 2 | Furthermore, we found that curcumin could down-regulate the expression of Hippo pathway effectors, YAP and TAZ, which have been reported to protect KLF5 protein from degradation. | Curcumin | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |
| 3 | Thus, our data indicates that curcumin promotes KLF5 proteasome-dependent degradation through targeting YAP/TAZ in bladder cancer cells and also suggests the therapeutic potential of curcumin in the treatment of bladder cancer. | Curcumin | tafazzin, phospholipid-lysophospholipid transacylase | Mus musculus |