Title : Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.

Pub. Date : 2016 Mar

PMID : 25155366






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Steroids growth differentiation factor 9 Homo sapiens
2 Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Steroids growth differentiation factor 9 Homo sapiens
3 Human GDF9 with BMP15 (GDF9+BMP15) stimulated an increase in (3)H-thymidine incorporation (P<0.001), which was greater than the increase with BMP15 alone, while GDF9 alone had no effect. h-thymidine growth differentiation factor 9 Homo sapiens
4 Human GDF9 with BMP15 (GDF9+BMP15) stimulated an increase in (3)H-thymidine incorporation (P<0.001), which was greater than the increase with BMP15 alone, while GDF9 alone had no effect. h-thymidine growth differentiation factor 9 Homo sapiens
5 The stimulation of (3)H-thymidine incorporation by GDF9+BMP15 was reduced by the addition of inhibitors to the SMAD2/3, nuclear factor-KB (NF-KB) and c-Jun N-terminal kinase (JNK) signalling pathways. h-thymidine growth differentiation factor 9 Homo sapiens