Pub. Date : 2014 Oct 2
PMID : 25132361
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson"s disease: involvement of ERK1/2-Nrf2 signaling pathway. | gastrodin | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson"s disease: involvement of ERK1/2-Nrf2 signaling pathway. | gastrodin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | The present study evaluates the hypothesis that prevention of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor deficits by gastrodin might mainly result from its antioxidant property via interrupting extracellular signal regulated protein kinases (ERK) 1/2-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. | gastrodin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | Interestingly, MPTP-intoxicated mice treated with gastrodin robustly increased heme oxygenase 1, superoxide dismutase, glutathione levels, and Nrf2 nuclear translocation in striatum of MPTP-intoxicated mice. | gastrodin | heme oxygenase 1 | Mus musculus |
| 5 | Interestingly, MPTP-intoxicated mice treated with gastrodin robustly increased heme oxygenase 1, superoxide dismutase, glutathione levels, and Nrf2 nuclear translocation in striatum of MPTP-intoxicated mice. | gastrodin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 6 | SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. | gastrodin | mitogen-activated protein kinase 3 | Mus musculus |
| 7 | SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. | gastrodin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 8 | SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. | gastrodin | mitogen-activated protein kinase 3 | Mus musculus |
| 9 | SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. | gastrodin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |