Title : Cardiac myocyte-specific AHR activation phenocopies TCDD-induced toxicity in zebrafish.

Pub. Date : 2014 Sep

PMID : 25037585






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1 Cardiac myocyte-specific AHR activation phenocopies TCDD-induced toxicity in zebrafish. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio
2 Exposure of zebrafish embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the zebrafish aryl hydrocarbon receptor 2 (AHR) to produce developmental and cardiovascular toxicity. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio
3 Exposure of zebrafish embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the zebrafish aryl hydrocarbon receptor 2 (AHR) to produce developmental and cardiovascular toxicity. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio
4 Exposure of zebrafish embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the zebrafish aryl hydrocarbon receptor 2 (AHR) to produce developmental and cardiovascular toxicity. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio
5 Exposure of zebrafish embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the zebrafish aryl hydrocarbon receptor 2 (AHR) to produce developmental and cardiovascular toxicity. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio
6 AHR is found in the heart; however, AHR activation by TCDD is not confined to the heart and occurs throughout the organism. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio
7 AHR is found in the heart; however, AHR activation by TCDD is not confined to the heart and occurs throughout the organism. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio
8 We show that AHR activation within the cardiomyocytes can account for the heart failure induced by TCDD. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor 2 Danio rerio