Title : Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.

Pub. Date : 2014 Oct

PMID : 25024286






6 Functional Relationships(s)
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Protein Name
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1 Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production. Reactive Oxygen Species sestrin 2 Mus musculus
2 Sestrin2, a highly conserved antioxidant protein, regulates intracellular ROS level by regenerating hyperoxidized peroxiredoxins. Reactive Oxygen Species sestrin 2 Mus musculus
3 We hypothesized that sestrin2 may be involved in preventing excessive renal ROS production and thus contribute to the maintenance of normal blood pressure. Reactive Oxygen Species sestrin 2 Mus musculus
4 Moreover, the D2R may decrease ROS production, in part, through the regulation of sestrin2. Reactive Oxygen Species sestrin 2 Mus musculus
5 Silencing sestrin2 in renal proximal tubule cells increased hyperoxidized peroxiredoxins (2.1-fold) and ROS production (1.3-fold). Reactive Oxygen Species sestrin 2 Mus musculus
6 Silencing sestrin2 also abolished D2R-induced decrease in peroxiredoxin hyperoxidation and partially prevented the inhibitory effect of D2R stimulation on ROS production. Reactive Oxygen Species sestrin 2 Mus musculus