Title : Preventive effects of siRNA targeting PPARγ gene on steroid-induced osteonecrosis in rabbits.

Pub. Date : 2014 Oct-Dec

PMID : 25000369






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1 RESULTS: The levels of PPARgamma gene expression were decreased while the levels of osteocalcin and Runx2 gene expression were increased in rabbits treated with dexamethasone and recombinant adenovirus shuttle vector carrying siRNA targeting PPARgamma gene (Group S), compared to rabbits treated either with dexamethasone alone (Group M) or with both dexamethasone and a vector carrying irrelative sequence (Group Con). Dexamethasone osteocalcin Oryctolagus cuniculus