Title : Metabolism of vasoactive peptides by vascular endothelium and smooth muscle aminopeptidase M.

Pub. Date : 1989 Jan 1

PMID : 2462880






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Proportional to its cellular distribution, AmM hydrolyzed the N-terminus of kallidin to produce bradykinin, and degraded des(Asp1)angiotensin I, angiotensin III, hepta(5-11)substance P and Met5-enkephalin. Heptachlor alanyl aminopeptidase, membrane Homo sapiens
2 Des(Asp1)angiotensin I and angiotensin III had the highest affinity (lowest Km) for AmM (Km = 2.2 +/- 0.5 and 2.0 +/- 0.4 microM respectively), followed by hepta(5-11)substance P (53.9 +/- 1.7 microM) and Met5-enkephalin (75.7 +/- 3.5 microM). Heptachlor beta-secretase 2 Homo sapiens
3 Des(Asp1)angiotensin I and angiotensin III had the highest affinity (lowest Km) for AmM (Km = 2.2 +/- 0.5 and 2.0 +/- 0.4 microM respectively), followed by hepta(5-11)substance P (53.9 +/- 1.7 microM) and Met5-enkephalin (75.7 +/- 3.5 microM). Heptachlor alanyl aminopeptidase, membrane Homo sapiens