Pub. Date : 2015 Mar
PMID : 24621440
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cabozantinib reverses multidrug resistance of human hepatoma HepG2/adr cells by modulating the function of P-glycoprotein. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | This study assessed the mechanistic effect of cabozantinib on the reversal of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | This study assessed the mechanistic effect of cabozantinib on the reversal of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The binding mechanism of cabozantinib to P-gp at the molecular level was evaluated using docking analysis. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | RESULTS: Cabozantinib enhanced the cytotoxicity of P-gp substrate drugs in HepG2/adr and HEK293-MDR1 cells but had no effect on non-P-gp substrates. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | In addition, cabozantinib increased the accumulation of P-gp substrates in HepG2/adr cells but had no effect in HepG2 cells. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Furthermore, cabozantinib did not alter the expression of P-gp mRNA or protein but did stimulate the activity of P-gp ATPase. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | The docking study indicated that cabozantinib and verapamil may partially share a binding site on P-gp. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | Significantly, cabozantinib increased the inhibitory efficacy of doxorubicin in P-gp-overexpressing HepG2/adr cell xenografts in nude mice. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 10 | CONCLUSION: Cabozantinib reverses P-gp-mediated MDR by directly inhibiting the efflux function of P-gp, indicating that cabozantinib may help to reverse P-gp-mediated MDR in HCC and other cancer chemotherapy. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 11 | CONCLUSION: Cabozantinib reverses P-gp-mediated MDR by directly inhibiting the efflux function of P-gp, indicating that cabozantinib may help to reverse P-gp-mediated MDR in HCC and other cancer chemotherapy. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 12 | CONCLUSION: Cabozantinib reverses P-gp-mediated MDR by directly inhibiting the efflux function of P-gp, indicating that cabozantinib may help to reverse P-gp-mediated MDR in HCC and other cancer chemotherapy. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 13 | CONCLUSION: Cabozantinib reverses P-gp-mediated MDR by directly inhibiting the efflux function of P-gp, indicating that cabozantinib may help to reverse P-gp-mediated MDR in HCC and other cancer chemotherapy. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 14 | CONCLUSION: Cabozantinib reverses P-gp-mediated MDR by directly inhibiting the efflux function of P-gp, indicating that cabozantinib may help to reverse P-gp-mediated MDR in HCC and other cancer chemotherapy. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 15 | CONCLUSION: Cabozantinib reverses P-gp-mediated MDR by directly inhibiting the efflux function of P-gp, indicating that cabozantinib may help to reverse P-gp-mediated MDR in HCC and other cancer chemotherapy. | cabozantinib | ATP binding cassette subfamily B member 1 | Homo sapiens |