Title : SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development.

Pub. Date : 2013 Nov 1

PMID : 24505507






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 This genetic synergy stands in contrast to the epistasis we have previously reported between Sestd1 and Dact1 KO, and suggests independent or semi-independent functions for Dvl2 vs. Sestd1/Dact1 in the regulation of the PCP pathway during development. pcp dishevelled binding antagonist of beta catenin 1 Homo sapiens
2 In conclusion, biochemical and genetic interactions between Dvl2, Sestd1, and Dact1, in addition to prior reported interactions between these same molecules and Vangl2, suggest that all these gene products can form complexes together and regulate the PCP pathway during mammalian development. pcp dishevelled binding antagonist of beta catenin 1 Homo sapiens