Title : Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability.

Pub. Date : 2014 Jan 14

PMID : 24385580






4 Functional Relationships(s)
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1 Increased tyrosine phosphorylation was observed at the plasma membrane of epithelial cells lining the crypts of the small bowel and colon of the PTPsigma(-/-) mouse, suggesting the presence of PTPsigma substrates in these regions. Tyrosine protein tyrosine phosphatase, receptor type, S Mus musculus
2 Increased tyrosine phosphorylation was observed at the plasma membrane of epithelial cells lining the crypts of the small bowel and colon of the PTPsigma(-/-) mouse, suggesting the presence of PTPsigma substrates in these regions. Tyrosine protein tyrosine phosphatase, receptor type, S Mus musculus
3 Using mass spectrometry, we identified several putative PTPsigma intestinal substrates that were hyper-tyrosine-phosphorylated in the PTPsigma(-/-) mice relative to wild type. Tyrosine protein tyrosine phosphatase, receptor type, S Mus musculus
4 Using mass spectrometry, we identified several putative PTPsigma intestinal substrates that were hyper-tyrosine-phosphorylated in the PTPsigma(-/-) mice relative to wild type. Tyrosine protein tyrosine phosphatase, receptor type, S Mus musculus