Pub. Date : 2014 Dec
PMID : 24385142
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-citrulline (Cit) is a co-product of NO synthesis and a direct L-arginine (Arg) precursor for de novo NO synthesis. | Citrulline | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 2 | L-citrulline (Cit) is a co-product of NO synthesis and a direct L-arginine (Arg) precursor for de novo NO synthesis. | Arginine | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 3 | L-citrulline (Cit) is a co-product of NO synthesis and a direct L-arginine (Arg) precursor for de novo NO synthesis. | Arginine | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 4 | Acute liver failure (ALF) is associated with increased nitric oxide (NO) and cyclic GMP (cGMP) synthesis in the brain, indirectly implicating a role for active transport of Cit. | Cyclic GMP | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 5 | In the present study we characterized [(3)H]Cit uptake to the cortical brain slices obtained from control rats and rats with thioacetamide (TAA)-induced ALF ("TAA slices"). | Thioacetamide | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 6 | Cit uptake was not affected by Arg, the y(+)/y(+)L transport system substrate, nor by amino acids taken up by systems A, xc (-)or XAG. | Arginine | citron rho-interacting serine/threonine kinase | Rattus norvegicus |
| 7 | The activity of argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL), the two enzymes of Cit-NO cycle catalyzing synthesis of Arg, showed an increase in TAA rats, consistent with increased ASS and ASL protein expression, by ~30 and ~20 %, respectively. | Arginine | citron rho-interacting serine/threonine kinase | Rattus norvegicus |