Pub. Date : 1987 May
PMID : 2437290
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chlordecone (10-50 microM) increased [Ca++]i from the resting level of 370 nM in a dose- and time-dependent manner to above 1.5 microM. | Chlordecone | carbonic anhydrase 1 | Homo sapiens |
| 2 | Verapamil, a voltage sensitive Ca++ channel blocker, inhibited the initial increase of [Ca++]i caused by chlordecone, by 40%. | Chlordecone | carbonic anhydrase 1 | Homo sapiens |
| 3 | Chlordecone also elevated [Ca++]i in synaptosomes in which mitochondrial Ca++ uptake had been abolished by valinomycin. | Chlordecone | carbonic anhydrase 1 | Homo sapiens |
| 4 | The effect of chlordecone on [Ca++]i decreased when the total amount of tissue in incubations was increased. | Chlordecone | carbonic anhydrase 1 | Homo sapiens |