Title : Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs.

Pub. Date : 1985 Dec

PMID : 2419314






2 Functional Relationships(s)
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1 AY-9944 (trans-1,4-bis(2-chlorobenzylaminoethyl)cyclohexane dihydrochloride), a cationic amphiphilic drug, caused a rapid, irreversible and dose-dependent reduction of acid sphingomyelinase activity in normal human fibroblasts without changing the activities of other lysosomal hydrolases tested. trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride sphingomyelin phosphodiesterase 1 Homo sapiens
2 AY-9944 (trans-1,4-bis(2-chlorobenzylaminoethyl)cyclohexane dihydrochloride), a cationic amphiphilic drug, caused a rapid, irreversible and dose-dependent reduction of acid sphingomyelinase activity in normal human fibroblasts without changing the activities of other lysosomal hydrolases tested. trans-1,4-bis(2-chlorobenzylaminoethyl)cyclohexane dihydrochloride sphingomyelin phosphodiesterase 1 Homo sapiens