Title : Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast-like synoviocytes.

Pub. Date : 2013 Dec

PMID : 24107356






8 Functional Relationships(s)
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1 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat microRNA 146a Homo sapiens
2 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat microRNA 146a Homo sapiens
3 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat microRNA 146a Homo sapiens
4 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat microRNA 146a Homo sapiens
5 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat microRNA 146a Homo sapiens
6 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat microRNA 146a Homo sapiens
7 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat microRNA 146a Homo sapiens
8 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat microRNA 146a Homo sapiens