PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 17-21 microRNA 146a Homo sapiens 105-113 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 17-21 nuclear factor kappa B subunit 1 Homo sapiens 179-188 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 17-21 microRNA 146a Homo sapiens 196-204 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 17-21 interleukin 1 beta Homo sapiens 240-248 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 17-21 RELA proto-oncogene, NF-kB subunit Homo sapiens 269-272 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 17-21 interleukin 6 Homo sapiens 303-307 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 23-33 microRNA 146a Homo sapiens 105-113 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 23-33 nuclear factor kappa B subunit 1 Homo sapiens 179-188 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 23-33 microRNA 146a Homo sapiens 196-204 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 23-33 interleukin 1 beta Homo sapiens 240-248 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 23-33 RELA proto-oncogene, NF-kB subunit Homo sapiens 269-272 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Vorinostat 23-33 interleukin 6 Homo sapiens 303-307 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 40-46 microRNA 146a Homo sapiens 105-113 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 40-46 nuclear factor kappa B subunit 1 Homo sapiens 179-188 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 40-46 microRNA 146a Homo sapiens 196-204 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 40-46 interleukin 1 beta Homo sapiens 240-248 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 40-46 RELA proto-oncogene, NF-kB subunit Homo sapiens 269-272 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 40-46 interleukin 6 Homo sapiens 303-307 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 histone deacetylase 9 Homo sapiens 0-4 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 microRNA 146a Homo sapiens 105-113 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 nuclear factor kappa B subunit 1 Homo sapiens 179-188 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 microRNA 146a Homo sapiens 196-204 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 interleukin 1 beta Homo sapiens 240-248 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 RELA proto-oncogene, NF-kB subunit Homo sapiens 269-272 24107356-8 2013 HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion. Panobinostat 48-60 interleukin 6 Homo sapiens 303-307