Pub. Date : 2013 Dec
PMID : 24037421
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | E2F1-mediated DNA damage is implicated in 8-Cl-adenosine-induced chromosome missegregation and apoptosis in human lung cancer H1299 cells. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 2 | Here, we demonstrate that E2F1-mediated DNA damage is implicated in 8-Cl-Ado-induced chromosome missegregation and apoptosis in lung cancer H1299 cells. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 3 | We showed that E2F1 was accumulated upon 8-Cl-Ado-induced DNA DSBs. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 4 | Induction of E2F1 by 8-Cl-Ado caused DNA damage in cycling cells including M cells. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 5 | In contrast, silencing of E2F1 expression decreased 8-Cl-Ado-induced DNA DSBs, particularly eliminated E2F1-mediated mitotic DNA damage. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 6 | Furthermore, over-expression of E2F1 expression enhanced 8-Cl-Ado-induced apoptosis. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 7 | Together, our data indicate that E2F1-mediated DNA damage, in particular mitotic DNA damage, is an important fraction of 8-Cl-Ado-induced DNA damage, which is implicated in 8-Cl-Ado-induced mitotic catastrophe and delayed apoptosis. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 8 | Together, our data indicate that E2F1-mediated DNA damage, in particular mitotic DNA damage, is an important fraction of 8-Cl-Ado-induced DNA damage, which is implicated in 8-Cl-Ado-induced mitotic catastrophe and delayed apoptosis. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |
| 9 | Induction of E2F1 by 8-Cl-Ado may contribute at least partly to the drug-inhibited proliferation of cancer cells. | 8-chloroadenosine | E2F transcription factor 1 | Homo sapiens |