Protein Name | E2F transcription factor 1 |
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Organism | Homo sapiens |
Gene ID | 1869 |
Gene Symbol | E2F1 |
UniProt | Q01094 (E2F1_HUMAN), Q9BSD8 (Q9BSD8_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
403
Total Number of Articles : 553 |
Description |
E2F transcription factor 1 |
Gene Summary |
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] |
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Properties | |