Protein Name E2F transcription factor 1
Organism Homo sapiens
Gene ID 1869
Gene Symbol


UniProt Q01094 (E2F1_HUMAN), Q9BSD8 (Q9BSD8_HUMAN)
Relationships Total Number of functionally related compound(s) : 403
Total Number of Articles : 553

E2F transcription factor 1

Gene Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

  • transcription factor E2F1
  • PBR3
  • PRB-binding protein E2F-1
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