Pub. Date : 2013 Dec
PMID : 23876794
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study we revealed NuFkappaBeta as the upstream mediator involved in Btg2 transcription in response to cell stress challenges such as serum deprivation and oxidative stress i.e. H2O2, TPA or doxorubicin treatments in several cell lines. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |
| 2 | In the present study we revealed NuFkappaBeta as the upstream mediator involved in Btg2 transcription in response to cell stress challenges such as serum deprivation and oxidative stress i.e. H2O2, TPA or doxorubicin treatments in several cell lines. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |
| 3 | In the present study we revealed NuFkappaBeta as the upstream mediator involved in Btg2 transcription in response to cell stress challenges such as serum deprivation and oxidative stress i.e. H2O2, TPA or doxorubicin treatments in several cell lines. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 4 | We observed close interrelation between generation of reactive oxygen species (ROS), enhanced IkappaBalpha degradation, nuclear translocation of NuFkappaBeta (p65/RelA) and the significant increase of Btg2 expression independent of p53 status. | Reactive Oxygen Species | BTG anti-proliferation factor 2 | Homo sapiens |
| 5 | Generation of ROS was the common event mediating NuFkappaBeta activation and Btg2 transcription. | Reactive Oxygen Species | BTG anti-proliferation factor 2 | Homo sapiens |
| 6 | Furthermore, PKC activation was also found to be a critical factor mediating ROS-mediated signals to NFkappaB pathway that culminate on Btg2 regulation, and specifically PKC-delta was responsible for this regulation under oxidative stress. | Reactive Oxygen Species | BTG anti-proliferation factor 2 | Homo sapiens |
| 7 | However, serum deprivation-associated ROS generation bypassed PKC activation for induction of Btg2 expression via NFkappaB activation. | Reactive Oxygen Species | BTG anti-proliferation factor 2 | Homo sapiens |
| 8 | The present data imply that oxidative stress upregulates Btg2 expression via ROS-PKC-NuFkappaBeta cascade, independent of p53 status that in turn could be involved in mediating various biological phenotypes depending on the cellular context. | Reactive Oxygen Species | BTG anti-proliferation factor 2 | Homo sapiens |