Title : An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin.

Pub. Date : 1990 Apr

PMID : 2384057






1 Functional Relationships(s)
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1 This was reflected in kinetic studies using lung and liver microsomes, which showed that NADPH-cytochrome P-450 reductase had a lower affinity (Km) for paraquat and nitrofurantoin than for menadione and diquat, although values of Vmax were comparable for all the substrates except nitrofurantoin, which was lower. Paraquat cytochrome p450 oxidoreductase Rattus norvegicus