Title : Novel substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase.

Pub. Date : 1990 May 15

PMID : 2372538






3 Functional Relationships(s)
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1 All these new activities display the characteristics expected for the normal PAM-catalyzed reductive oxygenation pathway and produce an equimolar amount of glyoxylate together with the heteroatom-containing dealkylation products. glyoxylic acid peptidylglycine alpha-amidating monooxygenase Homo sapiens
2 Finally, we introduce several small non-peptide substrates for PAM by demonstrating that PAM catalyzes the transformation of hippuric acid and several ring-substituted derivatives to the corresponding benzamides and glyoxylic acid, with the most facile substrate of this class being 4-nitrohippuric acid. glyoxylic acid peptidylglycine alpha-amidating monooxygenase Homo sapiens
3 Finally, we introduce several small non-peptide substrates for PAM by demonstrating that PAM catalyzes the transformation of hippuric acid and several ring-substituted derivatives to the corresponding benzamides and glyoxylic acid, with the most facile substrate of this class being 4-nitrohippuric acid. glyoxylic acid peptidylglycine alpha-amidating monooxygenase Homo sapiens