| Protein Name | peptidylglycine alpha-amidating monooxygenase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5066 |
| Gene Symbol | PAM |
| UniProt | P19021 (AMD_HUMAN), O43832 (O43832_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
749
Total Number of Articles : 631 |
Description |
peptidylglycine alpha-amidating monooxygenase |
| Gene Summary |
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
| synonyms |
|
| Properties | |