Protein Name peptidylglycine alpha-amidating monooxygenase
Organism Homo sapiens
Gene ID 5066
Gene Symbol


UniProt P19021 (AMD_HUMAN), O43832 (O43832_HUMAN)
Relationships Total Number of functionally related compound(s) : 749
Total Number of Articles : 631

peptidylglycine alpha-amidating monooxygenase

Gene Summary

This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

  • peptidyl-glycine alpha-amidating monooxygenase
  • pancreatic peptidylglycine alpha-amidating monooxygenase
  • peptidyl alpha-amidating enzyme
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