Pub. Date : 2013 May
PMID : 23474074
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of mitochondrial serine hydroxymethyltransferase, the enzyme converting l-serine to glycine, assures an adequate supply of glycine to rapidly proliferating cancer cells. | Serine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 2 | Overexpression of mitochondrial serine hydroxymethyltransferase, the enzyme converting l-serine to glycine, assures an adequate supply of glycine to rapidly proliferating cancer cells. | Glycine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 3 | Overexpression of mitochondrial serine hydroxymethyltransferase, the enzyme converting l-serine to glycine, assures an adequate supply of glycine to rapidly proliferating cancer cells. | Glycine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 4 | Our hypothesis is that mitochondrial serine hydroxymethyltransferase is fundamental to sustain cancer metabolism since production of glycine fuels heme biosynthesis and therefore oxidative phosphorylation. | Glycine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 5 | Our hypothesis is that mitochondrial serine hydroxymethyltransferase is fundamental to sustain cancer metabolism since production of glycine fuels heme biosynthesis and therefore oxidative phosphorylation. | Heme | serine hydroxymethyltransferase 2 | Homo sapiens |
| 6 | Respiration of cancer cells may then ultimately rely on endogenous glycine synthesis by mitochondrial serine hydroxymethyltransferase. | Glycine | serine hydroxymethyltransferase 2 | Homo sapiens |
| 7 | If the observed increase of glycine consumption in rapidly proliferating cancer cells has its basis in the need for heme biosynthesis, then mitochondrial serine hydroxymethyltransferase should be considered as a key target for the development of new chemotherapeutic agents. | Glycine | serine hydroxymethyltransferase 2 | Homo sapiens |