Pub. Date : 2013 Apr 15
PMID : 23418090
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation. | Oxygen | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 2 | Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation. | Oxygen | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 3 | These results suggest that ET-1 induces a PASMC-specific increase in HIF-1alpha levels by upregulation of HIF-1alpha synthesis and downregulation of PHD2-mediated degradation, thereby amplifying the induction of HIF-1alpha in PASMCs during moderate, prolonged hypoxia. | pasmc | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |