PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23418090-6	2013	Levels of the oxygen-sensitive HIF-1alpha subunit and expression of HIF target genes were increased in both hypoxic cells and cells treated with ET-1.	Oxygen	14-20	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	31-41	
23418090-6	2013	Levels of the oxygen-sensitive HIF-1alpha subunit and expression of HIF target genes were increased in both hypoxic cells and cells treated with ET-1.	Oxygen	14-20	endothelin 1	Rattus norvegicus	145-149	
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	endothelin 1	Rattus norvegicus	17-21	
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	109-129	
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	131-135	
23418090-7	2013	Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation.	Oxygen	200-204	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	185-195	
23418090-8	2013	The induction of HIF-1alpha by moderate, prolonged hypoxia was blocked by BQ-123, an antagonist of ET-1 receptor subtype A.	cyclo(Trp-Asp-Pro-Val-Leu)	74-80	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	17-27	
23418090-8	2013	The induction of HIF-1alpha by moderate, prolonged hypoxia was blocked by BQ-123, an antagonist of ET-1 receptor subtype A.	cyclo(Trp-Asp-Pro-Val-Leu)	74-80	endothelin 1	Rattus norvegicus	99-103	
23418090-9	2013	The effects of ET-1 were mediated by increased intracellular calcium, generation of reactive oxygen species, and ERK1/2 activation.	Calcium	61-68	endothelin 1	Rattus norvegicus	15-19	
23418090-9	2013	The effects of ET-1 were mediated by increased intracellular calcium, generation of reactive oxygen species, and ERK1/2 activation.	Reactive Oxygen Species	84-107	endothelin 1	Rattus norvegicus	15-19	
23418090-11	2013	These results suggest that ET-1 induces a PASMC-specific increase in HIF-1alpha levels by upregulation of HIF-1alpha synthesis and downregulation of PHD2-mediated degradation, thereby amplifying the induction of HIF-1alpha in PASMCs during moderate, prolonged hypoxia.	pasmc	42-47	endothelin 1	Rattus norvegicus	27-31	
23418090-11	2013	These results suggest that ET-1 induces a PASMC-specific increase in HIF-1alpha levels by upregulation of HIF-1alpha synthesis and downregulation of PHD2-mediated degradation, thereby amplifying the induction of HIF-1alpha in PASMCs during moderate, prolonged hypoxia.	pasmc	42-47	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	69-79	
23418090-11	2013	These results suggest that ET-1 induces a PASMC-specific increase in HIF-1alpha levels by upregulation of HIF-1alpha synthesis and downregulation of PHD2-mediated degradation, thereby amplifying the induction of HIF-1alpha in PASMCs during moderate, prolonged hypoxia.	pasmc	42-47	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	149-153	
23418090-11	2013	These results suggest that ET-1 induces a PASMC-specific increase in HIF-1alpha levels by upregulation of HIF-1alpha synthesis and downregulation of PHD2-mediated degradation, thereby amplifying the induction of HIF-1alpha in PASMCs during moderate, prolonged hypoxia.	pasmc	42-47	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	106-116	
23418090-11	2013	These results suggest that ET-1 induces a PASMC-specific increase in HIF-1alpha levels by upregulation of HIF-1alpha synthesis and downregulation of PHD2-mediated degradation, thereby amplifying the induction of HIF-1alpha in PASMCs during moderate, prolonged hypoxia.	pasmcs	226-232	endothelin 1	Rattus norvegicus	27-31	
23418090-11	2013	These results suggest that ET-1 induces a PASMC-specific increase in HIF-1alpha levels by upregulation of HIF-1alpha synthesis and downregulation of PHD2-mediated degradation, thereby amplifying the induction of HIF-1alpha in PASMCs during moderate, prolonged hypoxia.	pasmcs	226-232	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	69-79