Pub. Date : 2013 Jan 15
PMID : 23142599
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio). | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 2 | Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio). | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 3 | To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost. | Dioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 4 | To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost. | Dioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 5 | In comparison, a splice-blocking AHR2 morpholino used to down-regulate ahr2 expression significantly reduced the inhibition of vtg1, vtg2 and vtg3 by 400 pptr 2,3,7,8-TCDD (20.7-27.4% rescue). | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 6 | In comparison, a splice-blocking AHR2 morpholino used to down-regulate ahr2 expression significantly reduced the inhibition of vtg1, vtg2 and vtg3 by 400 pptr 2,3,7,8-TCDD (20.7-27.4% rescue). | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 7 | These studies demonstrate that 2,3,7,8-TCDD directly inhibits the vitellogenin pathway in vivo through activation of the AHR2. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |