PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23142599-0 2013 Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio). Polychlorinated Dibenzodioxins 45-80 vitellogenin Danio rerio 14-26 23142599-0 2013 Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio). Polychlorinated Dibenzodioxins 45-80 aryl hydrocarbon receptor 2 Danio rerio 96-123 23142599-0 2013 Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio). Polychlorinated Dibenzodioxins 45-80 aryl hydrocarbon receptor 2 Danio rerio 125-129 23142599-3 2013 To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost. Dioxins 157-163 vitellogenin Danio rerio 41-53 23142599-3 2013 To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost. Dioxins 157-163 aryl hydrocarbon receptor 2 Danio rerio 119-146 23142599-3 2013 To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost. Dioxins 157-163 aryl hydrocarbon receptor 2 Danio rerio 148-152 23142599-3 2013 To better understand chemical effects on vitellogenin gene regulation, we tested the hypothesis that activation of the aryl hydrocarbon receptor 2 (AHR2) by dioxin inhibits the estrogen receptor pathway regulation of 3 vitellogenin genes (vtg1-3) in vivo, using zebrafish (Danio rerio) as a model teleost. Dioxins 157-163 vitellogenin Danio rerio 219-231 23142599-5 2013 Pre-treatment with 400 pptr 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) or 1,2,3,7,8-pentachlorodibenzo-p-dioxin inhibited the EE2 induction of vtg1, vtg2 and vtg3 by >95% (p<=0.05). Polychlorinated Dibenzodioxins 28-63 vitellogenin 1 Danio rerio 151-155 23142599-5 2013 Pre-treatment with 400 pptr 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) or 1,2,3,7,8-pentachlorodibenzo-p-dioxin inhibited the EE2 induction of vtg1, vtg2 and vtg3 by >95% (p<=0.05). Polychlorinated Dibenzodioxins 28-63 vitellogenin 2 Danio rerio 157-161 23142599-5 2013 Pre-treatment with 400 pptr 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) or 1,2,3,7,8-pentachlorodibenzo-p-dioxin inhibited the EE2 induction of vtg1, vtg2 and vtg3 by >95% (p<=0.05). Polychlorinated Dibenzodioxins 28-63 vitellogenin 3, phosvitinless Danio rerio 166-170 23142599-5 2013 Pre-treatment with 400 pptr 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) or 1,2,3,7,8-pentachlorodibenzo-p-dioxin inhibited the EE2 induction of vtg1, vtg2 and vtg3 by >95% (p<=0.05). 1,2,3,7,8-pentachlorodibenzo-p-dioxin 82-119 vitellogenin 1 Danio rerio 151-155 23142599-5 2013 Pre-treatment with 400 pptr 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) or 1,2,3,7,8-pentachlorodibenzo-p-dioxin inhibited the EE2 induction of vtg1, vtg2 and vtg3 by >95% (p<=0.05). 1,2,3,7,8-pentachlorodibenzo-p-dioxin 82-119 vitellogenin 2 Danio rerio 157-161 23142599-5 2013 Pre-treatment with 400 pptr 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) or 1,2,3,7,8-pentachlorodibenzo-p-dioxin inhibited the EE2 induction of vtg1, vtg2 and vtg3 by >95% (p<=0.05). 1,2,3,7,8-pentachlorodibenzo-p-dioxin 82-119 vitellogenin 3, phosvitinless Danio rerio 166-170 23142599-6 2013 In comparison, a splice-blocking AHR2 morpholino used to down-regulate ahr2 expression significantly reduced the inhibition of vtg1, vtg2 and vtg3 by 400 pptr 2,3,7,8-TCDD (20.7-27.4% rescue). Polychlorinated Dibenzodioxins 159-171 aryl hydrocarbon receptor 2 Danio rerio 33-37 23142599-6 2013 In comparison, a splice-blocking AHR2 morpholino used to down-regulate ahr2 expression significantly reduced the inhibition of vtg1, vtg2 and vtg3 by 400 pptr 2,3,7,8-TCDD (20.7-27.4% rescue). Polychlorinated Dibenzodioxins 159-171 aryl hydrocarbon receptor 2 Danio rerio 71-75 23142599-6 2013 In comparison, a splice-blocking AHR2 morpholino used to down-regulate ahr2 expression significantly reduced the inhibition of vtg1, vtg2 and vtg3 by 400 pptr 2,3,7,8-TCDD (20.7-27.4% rescue). Polychlorinated Dibenzodioxins 159-171 vitellogenin 1 Danio rerio 127-131 23142599-6 2013 In comparison, a splice-blocking AHR2 morpholino used to down-regulate ahr2 expression significantly reduced the inhibition of vtg1, vtg2 and vtg3 by 400 pptr 2,3,7,8-TCDD (20.7-27.4% rescue). Polychlorinated Dibenzodioxins 159-171 vitellogenin 2 Danio rerio 133-137 23142599-6 2013 In comparison, a splice-blocking AHR2 morpholino used to down-regulate ahr2 expression significantly reduced the inhibition of vtg1, vtg2 and vtg3 by 400 pptr 2,3,7,8-TCDD (20.7-27.4% rescue). Polychlorinated Dibenzodioxins 159-171 vitellogenin 3, phosvitinless Danio rerio 142-146 23142599-7 2013 These studies demonstrate that 2,3,7,8-TCDD directly inhibits the vitellogenin pathway in vivo through activation of the AHR2. Polychlorinated Dibenzodioxins 31-43 vitellogenin Danio rerio 66-78 23142599-7 2013 These studies demonstrate that 2,3,7,8-TCDD directly inhibits the vitellogenin pathway in vivo through activation of the AHR2. Polychlorinated Dibenzodioxins 31-43 aryl hydrocarbon receptor 2 Danio rerio 121-125