Title : Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities.

Pub. Date : 2012 Jul-Aug

PMID : 23121983






4 Functional Relationships(s)
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1 In this evaluation, c-di-GMP was a more potent activator of both humoral and Th1-like immune responses as evidenced by the robust IgG2a antibody response it induced in mice and the strong IFN-gamma, TNF-alpha and IP-10 responses, it elicited in mice and in vitro in non-human primate peripheral blood mononuclear cells. bis(3',5')-cyclic diguanylic acid immunoglobulin heavy variable V1-9 Mus musculus
2 In this evaluation, c-di-GMP was a more potent activator of both humoral and Th1-like immune responses as evidenced by the robust IgG2a antibody response it induced in mice and the strong IFN-gamma, TNF-alpha and IP-10 responses, it elicited in mice and in vitro in non-human primate peripheral blood mononuclear cells. bis(3',5')-cyclic diguanylic acid interferon gamma Mus musculus
3 In this evaluation, c-di-GMP was a more potent activator of both humoral and Th1-like immune responses as evidenced by the robust IgG2a antibody response it induced in mice and the strong IFN-gamma, TNF-alpha and IP-10 responses, it elicited in mice and in vitro in non-human primate peripheral blood mononuclear cells. bis(3',5')-cyclic diguanylic acid tumor necrosis factor Mus musculus
4 In this evaluation, c-di-GMP was a more potent activator of both humoral and Th1-like immune responses as evidenced by the robust IgG2a antibody response it induced in mice and the strong IFN-gamma, TNF-alpha and IP-10 responses, it elicited in mice and in vitro in non-human primate peripheral blood mononuclear cells. bis(3',5')-cyclic diguanylic acid chemokine (C-X-C motif) ligand 10 Mus musculus