Title : Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats.

Pub. Date : 2013 Mar

PMID : 23113620






2 Functional Relationships(s)
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1 The mRNA and protein expression of Flt-1 and Flk-1 and the tissue concentration of LPO, TNF-alpha, and IL-1beta were upregulated significantly after the hypoxic exposure, whereas the content of GSH was decreased significantly. Glutathione Fms related receptor tyrosine kinase 1 Rattus norvegicus
2 Melatonin suppressed Flt-1 and Flk-1 expression in retinal blood vessels, which may result in reduced retinal vascular permeability and it also preserved mitochondrial function as shown by a reduction in cytochrome c leakage into the cytosol. Melatonin Fms related receptor tyrosine kinase 1 Rattus norvegicus