Pub. Date : 2012 Oct 17
PMID : 23077721
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 2 | We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 3 | We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators. | Hemicholinium 3 | solute carrier family 5 member 7 | Homo sapiens |
| 4 | We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators. | Hemicholinium 3 | solute carrier family 5 member 7 | Homo sapiens |
| 5 | Using this assay, we discovered that staurosporine increased CHT LV-AA choline uptake activity, an effect mediated by a decrease in choline K(M) with no change in V(max). | Staurosporine | solute carrier family 5 member 7 | Homo sapiens |
| 6 | Using this assay, we discovered that staurosporine increased CHT LV-AA choline uptake activity, an effect mediated by a decrease in choline K(M) with no change in V(max). | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 7 | Using this assay, we discovered that staurosporine increased CHT LV-AA choline uptake activity, an effect mediated by a decrease in choline K(M) with no change in V(max). | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 8 | Surprisingly, staurosporine reduced choline-induced membrane depolarization, suggesting that increased substrate coupling to ion gradients, arising at the expense of nonstoichiometric ion flow, accompanies a shift of CHT to a higher-affinity state. | Staurosporine | solute carrier family 5 member 7 | Homo sapiens |
| 9 | Surprisingly, staurosporine reduced choline-induced membrane depolarization, suggesting that increased substrate coupling to ion gradients, arising at the expense of nonstoichiometric ion flow, accompanies a shift of CHT to a higher-affinity state. | Choline | solute carrier family 5 member 7 | Homo sapiens |