Title : Histone H3 lysine 27 and 9 hypermethylation within the Bad promoter region mediates 5-Aza-2'-deoxycytidine-induced Leydig cell apoptosis: implications of 5-Aza-2'-deoxycytidine toxicity to male reproduction.

Pub. Date : 2013 Jan

PMID : 23065098






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we report that 5-Aza increased the apoptotic protein Bad epigenetically in the testosterone-producing mouse TM3 Leydig cell line. Azacitidine tropomyosin 1, alpha Mus musculus
2 Here, we report that 5-Aza increased the apoptotic protein Bad epigenetically in the testosterone-producing mouse TM3 Leydig cell line. Testosterone tropomyosin 1, alpha Mus musculus
3 Flow cytometric analysis further supported 5-Aza-derived apoptosis in TM3 cells. Azacitidine tropomyosin 1, alpha Mus musculus
4 In conclusion, our results demonstrate for the first time that Bad expression is regulated at least by EZH2-mediated H3K27-3me or G9a-like protein/euchromatic histone methyltransferase 1 (GLP/Eu-HMTase1)-mediated H3K9-3me in mouse TM3 Leydig cells, which may be implicated in 5-Aza-derived toxicity to male reproduction. Azacitidine tropomyosin 1, alpha Mus musculus