Pub. Date : 2012
PMID : 22937490
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High salt intake suppresses the expression of PHD2 in the renal medulla, which increases HIF-1alpha-mediated gene expressions in the renal medulla, thereby participates in the control of salt sensitivity of blood pressure. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 2 | High salt intake suppresses the expression of PHD2 in the renal medulla, which increases HIF-1alpha-mediated gene expressions in the renal medulla, thereby participates in the control of salt sensitivity of blood pressure. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 3 | 3) The high salt-induced inhibition in PHD2 and the consequent activation of HIF-1alpha in the renal medulla is not observed in Dahl salt sensitive hypertensive (Dahl/ss) rats. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 4 | Correction of these defects in PHD2/HIF-1alpha-associated molecular adaptation in the renal medulla improves sodium excretion, reduces sodium retention and attenuates saltsensitive hypertension in Dahl/ss rats. | Sodium | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 5 | Correction of these defects in PHD2/HIF-1alpha-associated molecular adaptation in the renal medulla improves sodium excretion, reduces sodium retention and attenuates saltsensitive hypertension in Dahl/ss rats. | Sodium | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 6 | In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 7 | In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 8 | In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 9 | In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 10 | In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |