PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22937490-0	2012	Hypoxia inducible factor-1alpha-mediated gene activation in the regulation of renal medullary function and salt sensitivity of blood pressure.	Salts	107-111	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-31	
22937490-5	2012	Interestingly, these enzymes are oxygen sensitive genes and regulated by transcription factor hypoxia-inducible factor (HIF)-1alpha.	Oxygen	33-39	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	94-131	
22937490-6	2012	Our recent serial studies have demonstrated that: 1) High salt intake stimulates HIF-1alpha-mediated gene expression, such as NOS, HO-1 and COX-2, in the renal medulla, which may augment the production of different antihypertensive factors in the renal medulla, mediating renal adaptation to high salt intake and regulating salt sensitivity of arterial blood pressure.	Salts	58-62	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	81-91	
22937490-6	2012	Our recent serial studies have demonstrated that: 1) High salt intake stimulates HIF-1alpha-mediated gene expression, such as NOS, HO-1 and COX-2, in the renal medulla, which may augment the production of different antihypertensive factors in the renal medulla, mediating renal adaptation to high salt intake and regulating salt sensitivity of arterial blood pressure.	Salts	58-62	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	140-145	
22937490-6	2012	Our recent serial studies have demonstrated that: 1) High salt intake stimulates HIF-1alpha-mediated gene expression, such as NOS, HO-1 and COX-2, in the renal medulla, which may augment the production of different antihypertensive factors in the renal medulla, mediating renal adaptation to high salt intake and regulating salt sensitivity of arterial blood pressure.	Salts	297-301	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	81-91	
22937490-6	2012	Our recent serial studies have demonstrated that: 1) High salt intake stimulates HIF-1alpha-mediated gene expression, such as NOS, HO-1 and COX-2, in the renal medulla, which may augment the production of different antihypertensive factors in the renal medulla, mediating renal adaptation to high salt intake and regulating salt sensitivity of arterial blood pressure.	Salts	297-301	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	81-91	
22937490-8	2012	High salt intake suppresses the expression of PHD2 in the renal medulla, which increases HIF-1alpha-mediated gene expressions in the renal medulla, thereby participates in the control of salt sensitivity of blood pressure.	Salts	5-9	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	46-50	
22937490-8	2012	High salt intake suppresses the expression of PHD2 in the renal medulla, which increases HIF-1alpha-mediated gene expressions in the renal medulla, thereby participates in the control of salt sensitivity of blood pressure.	Salts	5-9	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	89-99	
22937490-8	2012	High salt intake suppresses the expression of PHD2 in the renal medulla, which increases HIF-1alpha-mediated gene expressions in the renal medulla, thereby participates in the control of salt sensitivity of blood pressure.	Salts	187-191	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	46-50	
22937490-8	2012	High salt intake suppresses the expression of PHD2 in the renal medulla, which increases HIF-1alpha-mediated gene expressions in the renal medulla, thereby participates in the control of salt sensitivity of blood pressure.	Salts	187-191	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	89-99	
22937490-9	2012	3) The high salt-induced inhibition in PHD2 and the consequent activation of HIF-1alpha in the renal medulla is not observed in Dahl salt sensitive hypertensive (Dahl/ss) rats.	Salts	12-16	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	39-43	
22937490-9	2012	3) The high salt-induced inhibition in PHD2 and the consequent activation of HIF-1alpha in the renal medulla is not observed in Dahl salt sensitive hypertensive (Dahl/ss) rats.	Salts	12-16	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	77-87	
22937490-10	2012	Correction of these defects in PHD2/HIF-1alpha-associated molecular adaptation in the renal medulla improves sodium excretion, reduces sodium retention and attenuates saltsensitive hypertension in Dahl/ss rats.	Sodium	109-115	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	31-35	
22937490-10	2012	Correction of these defects in PHD2/HIF-1alpha-associated molecular adaptation in the renal medulla improves sodium excretion, reduces sodium retention and attenuates saltsensitive hypertension in Dahl/ss rats.	Sodium	109-115	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	36-46	
22937490-10	2012	Correction of these defects in PHD2/HIF-1alpha-associated molecular adaptation in the renal medulla improves sodium excretion, reduces sodium retention and attenuates saltsensitive hypertension in Dahl/ss rats.	Sodium	135-141	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	31-35	
22937490-10	2012	Correction of these defects in PHD2/HIF-1alpha-associated molecular adaptation in the renal medulla improves sodium excretion, reduces sodium retention and attenuates saltsensitive hypertension in Dahl/ss rats.	Sodium	135-141	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	36-46	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	136-140	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	15-19	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	136-140	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	34-44	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	261-265	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	15-19	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	261-265	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	158-162	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	261-265	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	177-187	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	261-265	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	15-19	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	261-265	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	158-162	
22937490-11	2012	In conclusion, PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla is an important molecular adaptation to high salt intake; impaired PHD2 regulation of HIF-1alpha-mediated gene activation in the renal medulla may be responsible for the salt-sensitive hypertension in Dahl/ss rats; correction of these defects may be used to as therapeutic strategies for the treatment of salt-sensitive hypertension.	Salts	261-265	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	177-187