Pub. Date : 2012 Oct
PMID : 22865232
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using MTT assays and real-time cell impedance measurements we confirmed the protective effect of AIF siRNA against glutamate toxicity in immortalized mouse hippocampal HT-22 neurons. | monooxyethylene trimethylolpropane tristearate | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |
| 2 | Using MTT assays and real-time cell impedance measurements we confirmed the protective effect of AIF siRNA against glutamate toxicity in immortalized mouse hippocampal HT-22 neurons. | Glutamic Acid | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |
| 3 | Further, AIF siRNA prevented glutamate-induced mitochondrial fragmentation and loss of mitochondrial membrane potential. | Glutamic Acid | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |
| 4 | Overall, these findings postulate that AIF depletion mediates a preconditioning effect protecting neuronal cells from subsequent glutamate toxicity through reduced levels of complex I protein. | Glutamic Acid | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |