Pub. Date : 2012 Sep 15
PMID : 22824864
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling. | PQQ Cofactor | epidermal growth factor receptor | Homo sapiens |
| 2 | The present study revealed that PQQ induces the activation (tyrosine autophosphorylation) of epidermal growth factor receptor (EGFR) and its downstream signaling in a ligand-independent manner, leading to increased cellular proliferation in an epithelial cell line A431. | PQQ Cofactor | epidermal growth factor receptor | Homo sapiens |
| 3 | The present study revealed that PQQ induces the activation (tyrosine autophosphorylation) of epidermal growth factor receptor (EGFR) and its downstream signaling in a ligand-independent manner, leading to increased cellular proliferation in an epithelial cell line A431. | PQQ Cofactor | epidermal growth factor receptor | Homo sapiens |
| 4 | PQQ inhibited protein tyrosine phosphatase 1B (PTP1B), which negatively regulates the EGFR signaling by tyrosine dephosphorylation, to oxidatively modify the catalytic cysteine through its redox cycling activity to generate H(2)O(2). | PQQ Cofactor | protein tyrosine phosphatase non-receptor type 1 | Homo sapiens |
| 5 | PQQ inhibited protein tyrosine phosphatase 1B (PTP1B), which negatively regulates the EGFR signaling by tyrosine dephosphorylation, to oxidatively modify the catalytic cysteine through its redox cycling activity to generate H(2)O(2). | PQQ Cofactor | epidermal growth factor receptor | Homo sapiens |
| 6 | PQQ-inducible intracellular ROS production and EGFR activation were significantly suppressed by the pre-treatment with antioxidants. | PQQ Cofactor | epidermal growth factor receptor | Homo sapiens |
| 7 | Our data suggest that PQQ may stimulate epithelial cell proliferation by activating EGFR by oxidation and subsequent inactivation of PTP1B via its redox cycling. | PQQ Cofactor | epidermal growth factor receptor | Homo sapiens |
| 8 | Our data suggest that PQQ may stimulate epithelial cell proliferation by activating EGFR by oxidation and subsequent inactivation of PTP1B via its redox cycling. | PQQ Cofactor | protein tyrosine phosphatase non-receptor type 1 | Homo sapiens |