Pub. Date : 2012 Oct
PMID : 22820510
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS/HYPOTHESIS: Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. | long-chain fatty acids | free fatty acid receptor 1 | Mus musculus |
| 2 | AIMS/HYPOTHESIS: Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. | Glucose | free fatty acid receptor 1 | Mus musculus |
| 3 | This study aimed to determine the mechanisms of GPR40-dependent potentiation of GSIS by fatty acids. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |
| 4 | Exogenous DAG potentiates GSIS in both WT and Gpr40 (-/-) islets. | Diglycerides | free fatty acid receptor 1 | Mus musculus |
| 5 | CONCLUSIONS/INTERPRETATION: We conclude that the signalling cascade downstream of GPR40 activation by fatty acids involves activation of PKD1, F-actin depolymerisation and potentiation of second-phase insulin secretion. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |