Title : [Study the effects of Salvia miltiorrhiza monomer IH764-3 on the expression of matrix metalloproteinase in lungs of rats exposed to Paraquat (PQ)].

Pub. Date : 2012 May

PMID : 22804981






3 Functional Relationships(s)
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1 OBJECTIVE: To observe the expression of the matrix metalloproteinase 2 (MMP-2) and membrane-type 1 metalloproteinase (MT1-MMP) in lung of rats exposed to paraquat (PQ) and the effects of Salvia miltiorrhiza monomer IH764-3 on above expression. Paraquat matrix metallopeptidase 14 Rattus norvegicus
2 OBJECTIVE: To observe the expression of the matrix metalloproteinase 2 (MMP-2) and membrane-type 1 metalloproteinase (MT1-MMP) in lung of rats exposed to paraquat (PQ) and the effects of Salvia miltiorrhiza monomer IH764-3 on above expression. Paraquat matrix metallopeptidase 14 Rattus norvegicus
3 CONCLUSION: The expression changes of MMP-2 and MT1-MMP genes of lungs in rats intragastrically exposed to PQ could result in the unbalance the synthesis and degradation of ECM, which may be a cause of lung fibrosis. Paraquat matrix metallopeptidase 14 Rattus norvegicus