Pub. Date : 2012 Nov
PMID : 22686466
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We recently reported that high salt intake suppressed the renal medullary PHD2 expression and thereby activated HIF-1alpha-mediated gene regulation in the renal medulla in response to high salt. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 2 | It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. | Sodium | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 3 | It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. | Sodium | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 4 | It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 5 | It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 6 | These results suggested that renal medullary PHD2 is an important regulator in renal adaptation to high salt intake and a deficiency in PHD2-mediated molecular adaptation in response to high salt intake in the renal medulla may represent a pathogenic mechanism producing salt sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 7 | These results suggested that renal medullary PHD2 is an important regulator in renal adaptation to high salt intake and a deficiency in PHD2-mediated molecular adaptation in response to high salt intake in the renal medulla may represent a pathogenic mechanism producing salt sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 8 | These results suggested that renal medullary PHD2 is an important regulator in renal adaptation to high salt intake and a deficiency in PHD2-mediated molecular adaptation in response to high salt intake in the renal medulla may represent a pathogenic mechanism producing salt sensitive hypertension. | Salts | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |