PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22686466-1 2012 Renal medullary hypoxia-inducible factor (HIF)-1alpha and its target genes, such as haem oxygenase and nitric oxide synthase, have been indicated to play an important role in the regulation of sodium excretion and blood pressure. Sodium 193-199 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 16-53 22686466-3 2012 We recently reported that high salt intake suppressed the renal medullary PHD2 expression and thereby activated HIF-1alpha-mediated gene regulation in the renal medulla in response to high salt. Salts 31-35 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 74-78 22686466-3 2012 We recently reported that high salt intake suppressed the renal medullary PHD2 expression and thereby activated HIF-1alpha-mediated gene regulation in the renal medulla in response to high salt. Salts 31-35 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 112-122 22686466-3 2012 We recently reported that high salt intake suppressed the renal medullary PHD2 expression and thereby activated HIF-1alpha-mediated gene regulation in the renal medulla in response to high salt. Salts 189-193 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 112-122 22686466-5 2012 It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. Sodium 174-180 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 36-40 22686466-5 2012 It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. Sodium 201-207 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 36-40 22686466-5 2012 It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. Salts 231-235 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 36-40 22686466-5 2012 It was shown that overexpression of PHD2 transgene increased PHD2 levels and decreased HIF-1alpha levels in the renal medulla, which blunted pressure natriuresis, attenuated sodium excretion, promoted sodium retention and produced salt sensitive hypertension after high salt challenge compared with rats treated with control plasmids. Salts 270-274 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 36-40 22686466-7 2012 These results suggested that renal medullary PHD2 is an important regulator in renal adaptation to high salt intake and a deficiency in PHD2-mediated molecular adaptation in response to high salt intake in the renal medulla may represent a pathogenic mechanism producing salt sensitive hypertension. Salts 104-108 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 45-49 22686466-7 2012 These results suggested that renal medullary PHD2 is an important regulator in renal adaptation to high salt intake and a deficiency in PHD2-mediated molecular adaptation in response to high salt intake in the renal medulla may represent a pathogenic mechanism producing salt sensitive hypertension. Salts 191-195 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 136-140 22686466-7 2012 These results suggested that renal medullary PHD2 is an important regulator in renal adaptation to high salt intake and a deficiency in PHD2-mediated molecular adaptation in response to high salt intake in the renal medulla may represent a pathogenic mechanism producing salt sensitive hypertension. Salts 191-195 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 136-140