Pub. Date : 2012 Jul
PMID : 22486217
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DAC-induced cytotoxicity is limited by the PARP1 inhibitor, 5-aminoisoquinolinone, supporting a role for apoptosis-inducing factor (AIF) in the apoptotic process. | aminochrome 1 | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |
| 2 | DAC-induced cytotoxicity is limited by the PARP1 inhibitor, 5-aminoisoquinolinone, supporting a role for apoptosis-inducing factor (AIF) in the apoptotic process. | aminochrome 1 | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |
| 3 | DAC-induced cytotoxicity is limited by the PARP1 inhibitor, 5-aminoisoquinolinone, supporting a role for apoptosis-inducing factor (AIF) in the apoptotic process. | 5-aminoisoquinolinone | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |
| 4 | Indeed, AIF is detected in the nuclear fraction of MN9D cells 3 h after DAC exposure. | aminochrome 1 | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |
| 5 | Taken together these results demonstrate that DAC induces cytotoxicity in MN9D cells in a caspase-independent apoptotic manner, likely triggered by oxidative damage to DNA, and involving the translocation of AIF from the mitochondria to the nucleus. | aminochrome 1 | apoptosis-inducing factor, mitochondrion-associated 1 | Mus musculus |