Title : Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.

Pub. Date : 2012 May 1

PMID : 22408025






2 Functional Relationships(s)
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1 Treatment of the isolated knockout myocytes with FK506, which inhibits the association of FKBP12.6 with the ryanodine receptor, restored contractile function. Tacrolimus FK506 binding protein 1b Mus musculus
2 These findings demonstrate that conditional deletion of CHF1/Hey2 in the myocardium leads to abnormalities in calcium handling mediated by FKBP12.6 that predispose to pressure overload-induced heart failure. Calcium FK506 binding protein 1b Mus musculus