Title : Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development.

Pub. Date : 2012 May 15

PMID : 22357656






2 Functional Relationships(s)
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1 However, the loss of fadd results in a proliferation defect and concomitant activation of the necroptosis pathway through RIP1/RIP3 activity, leading to an abnormal open fissure. fadd receptor interacting serine/threonine kinase 3 Homo sapiens
2 Thus, fadd has an essential physiological function in protecting the developing optic fissure neuroepithelium from RIP3-dependent necroptosis. fadd receptor interacting serine/threonine kinase 3 Homo sapiens